Jean-Christophe Panzer mRNA Vacc Biochem 2B03 2023

By dljclupanzer | Updated: Feb. 15, 2025, 7:27 a.m.

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A basic overview of the steps in mRNA vaccine manufacture.

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mRNA Vaccines & Their Production

By Jean-Christophe Panzer
Slide 1
Figure 1.
Slide 2
Image retrieved from: https://www.unicef.org/coronavirus/covid-19-vaccines-why-dose-donations-are-essential
Figure 2.
Slide 4
Image retrieved from: https://www.genome.gov/about-genomics/fact-sheets/COVID-19-mRNA-Vaccine-Production
Efficient
& High Yield
Slide 4
Slide 5
Slide 6
Slide 7
Slide 8
Slide 9
Slide 10
Slide 11
Slide 12
Slide 13
&
Figure 3.
Slide 14
Image retrieved from: https://www.japantimes.co.jp/news/2020/11/10/world/science-health-world/pfizers-ultracold-coronavirus-vaccine/ 
Figure 4.
Slide 15
Image retrieved from: https://doi.org/10.1038/s41392-022-01007-w

References (Figures)
All images created by myself with BioRender and ChemDraw unless otherwise specified. Animations obtained from Powtoon.
(Figure 1.; slide 2) COVID-19 vaccines: 5 reasons why dose donations are essential | UNICEF. https://www.unicef.org/coronavirus/covid-19-vaccines-why-dose-donations-are-essential (accessed 2023-10-09).

(Figure 2.; slide 3) COVID-19 mRNA Vaccine Production. Genome.gov. https://www.genome.gov/about-genomics/fact-sheets/COVID-19-mRNA-Vaccine-Production (accessed 2023-09-16).

(Figure 3.; slide 14) O’Donnell, C. Why Pfizer’s vaccine won’t be at the local pharmacy anytime soon. The Japan Times. https://www.japantimes.co.jp/news/2020/11/10/world/science-health-world/pfizers-ultracold-coronavirus-vaccine/ (accessed 2023-10-09).

(Figure 4.; slide 15) Qin, S.; Tang, X.; Chen, Y.; Chen, K.; Fan, N.; Xiao, W.; Zheng, Q.; Li, G.; Teng, Y.; Wu, M.; Song, X. mRNA-Based Therapeutics: Powerful and Versatile Tools to Combat Diseases. Sig Transduct Target Ther 2022, 7 (1), 1–35. DOI: https://doi.org/10.1038/s41392-022-01007-w.

References
1. Quast, I.; Tarlinton, D. B Cell Memory: Understanding COVID-19. Immunity 2021, 54 (2), 205–210. DOI: 10.1016/j.immuni.2021.01.014.
2. Rosa, S. S.; Prazeres, D. M. F.; Azevedo, A. M.; Marques, M. P. C. mRNA Vaccines Manufacturing: Challenges and Bottlenecks. Vaccine 2021, 39 (16), 2190–2200. DOI: 10.1016/j.vaccine.2021.03.038.
3. Whitley, J.; Zwolinski, C.; Denis, C.; Maughan, M.; Hayles, L.; Clarke, D.; Snare, M.; Liao, H.; Chiou, S.; Marmura, T.; et. al Development of mRNA Manufacturing for Vaccines and Therapeutics: mRNA Platform Requirements and Development of a Scalable Production Process to Support Early Phase Clinical Trials. Transl Res 2022, 242, 38–55. DOI: 10.1016/j.trsl.2021.11.009.
4. Shanmugasundaram, M.; Senthilvelan, A.; Kore, A. R. Recent Advances in Modified Cap Analogs: Synthesis, Biochemical Properties, and mRNA Based Vaccines. Chem Rec 2022, 22 (8), e202200005. DOI: 10.1002/tcr.202200005.
5. Wilson, B.; Geetha, K. M. Lipid Nanoparticles in the Development of mRNA Vaccines for COVID-19. J Drug Deliv Sci Technol 2022, 74, 103553. DOI: 10.1016/j.jddst.2022.103553.
6. Kowalski, P. S.; Rudra, A.; Miao, L.; Anderson, D. G. Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. Mol Ther 2019, 27 (4), 710–728. DOI: 10.1016/j.ymthe.2019.02.012.
7. Morais, P.; Adachi, H.; Yu, Y.-T. The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines. Front Cell Dev Biol 2021, 9, 789427. DOI: 10.3389/fcell.2021.789427.
8. General COVID-19: Vaccine Storage and Handling Guidance, 2023. https://www.health.gov.on.ca/en/pro/programs/publichealth/coronavirus/docs/vaccine/vaccine_storage_handling_pfizer_moderna.pdf (accessed 2023-09-24).
9. Uddin, M. N.; Roni, M. A. Challenges of Storage and Stability of mRNA-Based COVID-19 Vaccines. Vaccines (Basel) 2021, 9 (9), 1033. DOI: 10.3390/vaccines9091033.

Jean-Christophe Panzer mRNA Vacc Biochem 2B03 2023

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