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Sacubitril MOA

By jayshika.m | Updated: Oct. 18, 2018, 10:46 p.m.

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_abc Powtoon Transcript

Sacubitril
https://pubchem.ncbi.nlm.nih.gov/compound/ahu-377#section=Top
Prodrug
Drug
(Active)

Linked compound
(Inactive)

Enzymatic Reaction
LBQ657
Sacubitril
Neprilysin 
Inactive Particles
http://clinchem.aaccjnls.org/content/58/1/83
[CONC]
Naturietic Peptides
Blood vessels
Extracellular Fluid
Vasoconstricting Hormones 
Angiotensin 2
https://www.healthtap.com/
https://dailytimes.com.pk/269373/controversy-regarding-heart-failure-medicine-put-to-rest/
Valsartan
https://www.algerie-eco.com/2018/07/19/sante-le-ministere-de-la-sante-retire-16-lot-de-valsartan/
Lower blood pressure

Reduce hypertension

Prevent heart failure

Angiotensin Recepter Blocker 
Renin Angiotensin-Adosterone System 
Renin Angiotensin-Adosterone System 
Entresto
Sacubitril/Valsartan
https://www.novartis.com.au/

https://www.entresto.com/index.jsp

R.A.A.S
http://www.comprehensivephysiology.com/WileyCDA/CompPhysArticle/refId-c180002.html
https://publications.nigms.nih.gov/medbydesign/chapter1.html
Dizziness
K+
Hyperkalemia
Angioedma
SIDE 
EFFECTS

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